生命科學系

研究主題

1、天然活性物質分離及篩選
2、天然物保健食品開發
3、環境微生物
4、環境污染物分析

5、保健茶包開發

6、美妝用品及手工皂開發

n  研究計畫：

1.          台東漆樹果實、台東漆樹樹葉及台東漆樹根部抗癌活性成分之研究(NSC-97-2320-B-143-001)97年國科會研究計畫主持人。

2.          拜訪生態農村農村學研計畫，99年度經濟部協同主持人。

3.          學界協助中小企業科技關懷計畫，99年度經濟部金屬中心主持人。

4.          學界協助中小企業科技關懷計畫，100年度經濟部金屬中心主持人。

 

n   期刊論文：

通訊作者或第一作者:

1.      Lin K.W., Wang B.W.,Wu C.M., Yen M.H., Wei B.L.*, Hung C.F., Lin C.N.*

”Antioxidant prenylated phenols of Artocarpus plants attenuate ultraviolet radiation-induced damage on human

keratinocytes and fibroblasts”

Phytochemistry Letters 2015,14, 190–197

2.Lin K.W., Chen Wei B.L* Hung C.F., Lin CN.*

• Xanthine oxidase inhibitory lanostanoids from Ganoderma tsugae”
• 2013 , 89, 231–238

3.Wei B.L*, Chen Y.C., Hsu H.Y.^.

”Kazinol Q from Broussonetia kazinoki Enhances Cell Death Induced by Cu (ll) through the Increased Reactive Oxygen Species”

Molecules 2011, 16 ,3212-3221

4.Chiou W.F., Don M.J., Liao J.F. Wei B.L *

”Psoralidin inhibits LPS-induced iNOS expression via repressing Syk-mediated activation of PI3K-IKK-Iκβsignaling pathways. “

Eur. J. Pharmacol. 2011, 10;650(1):102-109.

5.Lin K.W., Liu C.H., Tu H.Y., Ko H.H., Wei B.L.*

”Antioxidant prenylflavonoids from Artocarpus communis and Artocarpus elasticus”

 Food Chemistry,2009,115,558-562

6. Maitraie D., Hung C.F. , Tu H.Y., Liou Y.T., Wei B.L.*,Yang S.C., Wang J.P., Lin C.N.*

”Synthesis, anti-inflammatory, and antioxidant activities of 18β-glycyrrhetinic acid derivatives as chemical mediators and xanthine oxidase inhibitors. ”

Bioorganic & Medicinal Chemistry,2009,17,2785-2792

7. Tu HY, Huang AM, Wei BL, Gan KH, Hour TC, Yang SC, Pu YS, Lin CN.

”Ursolic acid derivativthes induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species. ”

Bioorganic & Medicinal Chemistry,2009, 17,7265-74..

8. Wei B.L, Teng C.H., Wang J.P., Won S.J., Lin C.N.

“Synthetic 2',5'-dimethoxychalcones as G₂/M arrest-mediated apoptosis-inducing agents and inhibitors of nitric oxide production in rat macrophages. ”,Eur. J. Med. Chem. ,2007, 42 , 600-608.

9.Wei B.L., Weng J.R., Chiu P.H., Hung C.F., Wang J.P., Lin C.N.

“Antiinflammatory flavonoids from Artocarpus heterophyllus and

Artocarpus communis”, J. Agric. Food Chem.,2005 ,53,3867-3871.

 非通訊作者或第一作者:

1.Hung Y.P., Wang J.J., Wei B.L., Lee C.L.

 ”Effect of the salts of deep ocean water on the production of cordycepin and adenosine of Cordyceps militaris-fermented product. ”

AMB Express. 2015 ,5(1):140. doi: 10.1186/s13568-015-0140-5.

2.Wang L.C., Lung T.Y., Kung Y.H., Wang J.J., Tsai H.Y., Wei B.L., Pan T.M., Lee C.L.,*

 ”Enhanced Anti-Obesity Activities of Red Mold Dioscorea When Fermented Using Deep Ocean Water as the Culture Water”

Mar. Drugs 2013, 11, 3902-3925; doi:10.3390/md11103902

3.Chiou W.F., Ko H. C., Wei B.L.

  ”Evodia rutaecarpa and Three Major Alkaloids Abrogate Influenza A Virus (H1N1)-induced Chemokines Production and Cell Migration”

Evid Based Complement Alternat Med. 2011 http://dx.doi. org/10.1093/ ecam/nep238

4.Chiou W.F.,Chen C.C., Wei B.L.

”3,4-Di-O-Caffeoylquinic Acid Inhibits Angiotensin-II-induced Vascular Smooth Muscle Cell Proliferation and Migration by Downregulating the JNK and PI3K/Akt Signaling Pathways. ”

Evid Based Complement Alternat Med. 2011 http://dx.doi. org/10.1093/ ecam/nep140

 5. Chiou W.F.,Chen C.C., Wei B.L.

”8-Prenylkaempferol Suppresses Influenza A Virus-Induced RANTES Production in A549 Cells via Blocking PI3K-Mediated Transcriptional Activation of NF-{kappa}B and IRF3. ”

Evid Based Complement Alternat Med. 2011 http://dx.doi. org/10.1093/ ecam/nep0662.

6.Chen H.L., Lin K.W., Huang A.M., Tu H.Y., Wei B.L., Hour T.C., Yen M.H., Pu Y.S., Lin C.N.

“Terpenoids induce cell cycle arrest and apoptosis from the stems of Celastrus kusanoi associated with reactive oxygen species. “

J. Agric. Food Chem. 2010 ,58,3808-3812.

7.Lo Y.C., Chang Y.H., Wei B.L., Huang Y.L., Chiou W.F.

“Betulinic acid stimulates the differentiation and mineralization of osteoblastic MC3T3-E1 cells: involvement of BMP/Runx2 and beta-catenin signals. “

J. Agric. Food Chem. 2010 ,58,6643-9.

8.Lin K.W., Huang A.M., Tu H.Y., Weng J.R., Hour T.C.., Wei BL., Yang S.C., Wang J.P., Pu Y.S., Lin C.N.

”Phloroglucinols inhibit chemical mediators and xanthine oxidase, and protect cisplatin-induced cell death by reducing reactive oxygen species in normal human urothelial and bladder cancer cells. ”

J Agric.Food Chem. 2009 ,57,8782-7.

9. Lu Y.H., Wei B.L., Ko H.H., Lin C.N.

“DNA strand-scission by phloroglucinols and lignans from heartwood of Garcinia subelliptica Merr. and Justicia plants“    

  Phytochemistry, 2008, 69,225-233.

10.Wu C.C., Lu Y.H., Wei B.L., Yang S.C., Won S.J., Lin C.N.

“Phloroglucinols with prooxidant activity from Garcinia subelliptica. “

J. Nat. Prod. 2008,71,246-250.

11. Chen C.C., Tsai P.C., Wei B.L., Chiou W.F.

“8-Prenylkaempferol suppresses inducible nitric oxide synthase expression through interfering with JNK-mediated AP-1 pathway in murine macrophages“

Eur .J. Pharmacol., 2008,590,430-436.

12.Ko H.C., Wei B.L., Chiou W.F.

“The effect of medicinal plants used in Chinese folk medicine on

RANTES secretion by us-infected human epithelial cells. ”,

J. Ethnopharmacol., 2006,107, 205-210.

13.Chen H.L., Wang L.W., Su H.J., Wei B.L., Yang S.Z., Lin C.N.
“New terpenoids from Amentotaxus formosana ”,

 Org. Lett. , 2006,16,753-756

14.Lee W.S., Tsai W.J., Yeh P.H., Wei B.L., Chiou W.F.

“Divergent role of calcium on Aβ- and MPTP-induced cell death in SK-N-SH neuroblastoma. ” ,
Life Sci., 2006,78,1268-1275 .

15.Ho S.Y., Huang P.C., Guo H.R., Chang W.H., Chen R.J., Wei B.L., Wu W.J., Tai C., Wang Y.J.

“Mechanisms of apoptosis induction and cell cycle regulation in irradiated Leukemia U937 cells and enhancement by arsenic trioxide. ”,
Radiat. Res. , 2006,165,390-399.

16.Ko H.C., Wei B.L., Chiou W.F.

“Dual regulatory effect of plant extracts of Forsythia suspense on RANTES and MCP-1 secretion in influenza A virus-infected human bronchial epithelial cells.”,

 J. Ethnopharmacol., 2005,102,418-423.

17.Ko H.C., Kuo Y.H., Wei B.L., Chiou W.F.

“Laxifolone A suppresses LPS/IFN-gamma-induced NO synthesis by attenuating NF-kappaB translocation: role of NF-kappaB p105 level. ”,

Planta Med., 2005,71,514-519.